Drug/Hormone Interactions

Drugs that increase estrogen levels:

Pain/anti-inflammatory drugs: acetaminophen, propoxephene, nonsteroidal anti-inflammatory drugs like ibuprofen, aspirin
Antibiotics: sulfas, tetracyclines, penicillins cefazolins, erythromycins, quinilones
Anti-fungal drugs: miconazole, itraconazole, fluconazole, ketoconazole
Cholesterol lowering drugs: lovastatin, simvistatin (statins)
Antidepressants: fluoxitine, fluvoxamine, paroxetine, sertraline
Anti-psychotic medicines: thorazine, haloperidol
Heart and blood pressure medicine: propranolol, quinidine, amiodarone (also decreases testosterone production), coumadin, methyldopa
Antacids: omeprazole, cimetidine
Vitamins and nutrients: high-dose vitamin E, general dietary deficiencies, grapefruit
Abusive substances: alcohol, amphetamines, marijuana, cocaine

Drugs or substances that decrease estrogen levels:

Vitamins: high-dose vitamin C (also increases testosterone production), vitamin K, niacin
Drugs: phenobarbital, chlordiazepoxide, carbamepazine, trazodone, sulcrafate
Foods: soy products, vegetarian diets, cruciferous vegetables (broccoli, cauliflower), shellfish (oysters), resveratrol (grapes skin compound)

Drugs and substances that compete for testosterone or change metabolism indirectly:

Antifungal drugs: (as above)
Pesticides, spironolacone, some cancer chemotherapy drugs, thiazide diuretics, DHEA

Adapted from "The Testosterone Syndrome" by Eugene Shippen.